She has been engaged in clinical, scientific research and teaching of infectious diseases for more than 40 years. She is director of the National Key Laboratory of infectious diseases diagnosis and treatment, director of collaborative innovation center of infectious diseases diagnosis and treatment, director of the Department of biology and medicine, Ministry of education, vice president of Chinese Medical Association, vice president of Chinese Preventive Medicine Association, and chairman of International Association of human Microbiology. She also serves as the head of the technology and technology major project "prevention and control of major infectious diseases such as AIDS and viral hepatitis", "deputy director general of the" 11th Five-Year and 12th Five-Year "plan," the comprehensive prevention and control demonstration zone and field research ", and the head of the National Health Planning Commission's population health information expert advisory committee, and vice president of the China Health Information Association. It has undertaken more than 20 national key projects such as "863", "973" and "Tenth Five Year Plan" and key projects of the National Natural Science Foundation, and obtained 26 invention patents and 3 software copyrights. He has published more than 400 papers and more than 200 papers in SCI included magazines such as nature, lancet and NEJM. 

She has won 2 first prizes of national scientific and technological progress, 2 second prizes of national scientific and technological progress and 6 first prizes of provincial scientific and technological progress.

Chairman of Zhejiang digital medical and Health Technology Research Institute, chairman of infectious physicians branch of Chinese Medical Association, chairman of Microecology branch of Chinese Preventive Medicine Association, vice chairman of digital medicine branch of Chinese Medical Association, etc.